Development of Novel Pyrazolopyridine and Pyrazolopyrimidine Frameworks: Synthetic Strategies

تطوير مركّبات جديدة من البيرازولوبيريدين والبيرازولوبيريميدين: منهجيات التخليق العضوي

Abstract

This study reports the development of a new series of pyrazolo[4,3-b] pyridine and pyrazolo[1,5-a] pyrimidine derivatives designed as potential antischistosomal agents. A diverse set of fused nitrogen-containing heterocycles was successfully obtained and subjected to preliminary biological relevance assessment based on their structural features. These newly synthesized frameworks, belonging to scaffolds previously associated with notable antimicrobial and antiparasitic properties, demonstrate promising potential for further evaluation against Schistosoma species. The findings highlight the value of these heterocyclic systems as candidates for developing alternative therapies to complement existing schistosomiasis treatment strategies.